منابع مشابه
Cardiac cell lineages that form the heart.
Myocardial cells ensure the contractility of the heart, which also depends on other mesodermal cell types for its function. Embryological experiments had identified the sources of cardiac precursor cells. With the advent of genetic engineering, novel tools have been used to reconstruct the lineage tree of cardiac cells that contribute to different parts of the heart, map the development of card...
متن کاملStudy of Differentiation Potential of the Dedifferentiated Chondrocytes From Rat Articular Cartilage into Skeletal Cell Lineages
Purpose: Dedifferentiation of the chondrocyte from rat articular cartilage with multiple subcultures and study of the redifferentiation potential of the cells into bone, cartilage and fat cell lineages. Materials and Methods: In this experimental study, chondrocytes from rat articular cartilage were isolated and expanded through several successive subcultures during which the expression levels ...
متن کاملLandmarks and lineages in the developing heart.
One of the overarching concepts underpinning mammalian embryonic development is that of “regulation.” This implies that the lineage potential of a particular cell is broader than its actual fate. Although the influential experiments in this area performed by Hans Driesch in the late 1800s concerned the fate of individual embryonic blastomeres, the concept of regulative development has pervaded ...
متن کاملRadiation-induced expression of platelet endothelial cell adhesion molecule-1 in cerebral endothelial cells
Background: Radiation-induced molecular changes on the endothelial surface of brain arteriovenous malformations (AVM) may be used as markers for specific vascular targeting agents. In this study, we examined the level of expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) on brain endothelial cell surface after radiation treatment, with the aim of targeting the radiation-induc...
متن کاملNotch Signaling Functions as a Cell-Fate Switch between the Endothelial and Hematopoietic Lineages
Recent studies have begun to elucidate how the endothelial lineage is specified from the nascent mesoderm. However, the molecular mechanisms which regulate this process remain largely unknown. We hypothesized that Notch signaling might play an important role in specifying endothelial progenitors from the mesoderm, given that this pathway acts as a bipotential cell-fate switch on equipotent prog...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2008
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-008-0663-z